BIOELECTRICAL SIGNATURE AND SONIFICATION OF PORCINE BLOOD BEFORE AND AFTER RED LIGHT PHOTOBIOMODULATION: A PROOF-OF-CONCEPT STUDY
DOI:
https://doi.org/10.70187/recisatec.v6i1.407Keywords:
Photobiomodulation, BioelectricityAbstract
Blood constitutes a complex electroactive biological system whose bioelectrical properties emerge from interactions among cells, plasma, and membrane interfaces. Although extensively investigated under conventional biochemical and hematological parameters, its dynamic electrical behavior remains largely unexplored. This study presents a proof of concept for characterizing the bioelectrical signature of fresh porcine blood through direct electrical acquisition, spectral analysis, and scientific sonification, before and after photobiomodulation with red light (≈650 nm). Porcine blood, obtained from a slaughterhouse and analyzed immediately after collection to minimize activation of the coagulation cascade, was used as a translational model due to its high hematological similarity to human blood, thereby obviating the need for research ethics committee approval. Bioelectrical signals were compared with a simple electrolytic control (saline solution), modeled according to the Cole–Cole formalism, and converted to the acoustic domain while preserving their temporal and spectral characteristics. As an original contribution, the Normalized Bioelectroacoustic Index (IBAN) is proposed as a functional biomarker derived from the power spectral density of the sonified signal. The results indicate that blood exhibits an organized bioelectrical signature distinct from saline, and that photobiomodulation induces spectral redistribution consistent with functional cellular reorganization. Sonification revealed additional dynamic patterns, suggesting potential complementary diagnostic applications based on dynamic bioelectricity.
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