BIOMARKERS IN PEDIATRIC NEOPLASMS: BIOLOGICAL INTEGRATION AND TRANSLATIONAL APPLICABILITY
DOI:
https://doi.org/10.70187/recisatec.v6i1.418Keywords:
Biomarkers, Oncology, NeoplasmsAbstract
Biomarkers in pediatric neoplasms represent increasingly relevant tools in contemporary oncology due to their ability to reflect different aspects of tumor biological activity. However, their interpretation remains complex, since molecular, inflammatory, metabolic, therapeutic and developmental factors may influence their clinical expression. This study observed that biomarkers do not exclusively reflect neoplastic presence, but also the interaction between cellular proliferation, tumor necrosis, immune response, metabolic adaptation and the tumor microenvironment. In addition, childhood-specific characteristics, including immune maturation and persistence of physiological developmental pathways, further increase the interpretative complexity of these markers. Molecular, inflammatory and metabolic biomarkers demonstrate significant potential in understanding tumor heterogeneity and the biological dynamics of pediatric neoplasms. Nevertheless, isolated laboratory alterations present important limitations due to the simultaneous influence of infections, secondary inflammation, therapeutic effects and pediatric physiological variability. In this context, the clinical and translational application of biomarkers requires an integrated and biologically oriented approach. Furthermore, the findings discussed suggest that relevant biological alterations may precede conventional anatomical detectability, reinforcing the potential of biomarkers in understanding early and subclinical phases of pediatric tumor activity.
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