ANALYSIS OF THE CORRELATION OF INFLAMMATORY CYTOKINES AND DIC IN POLYTRAUMATED PATIENTS
DOI:
https://doi.org/10.53612/recisatec.v2i6.148Keywords:
Multiple trauma, cytokines, Disseminated Intravascular CoagulationAbstract
Disseminated intravascular coagulation (DIC) is characterized by in vivo activation of the coagulation system, which results in intravascular deposition of fibrin and excessive bleeding. The polytraumatized patient suffers from systemic inflammation mediated by inflammatory cytokines. In this context, the objective of the present study is to relate inflammatory cytokines with the condition of disseminated intravascular coagulation in polytraumatized patients. The literature review was carried out from the survey of scientific articles found in the main search platforms for scientific articles: ScienceDirect, PubMed, SciELO and BIREME, from March 2021 to March 2022, using the descriptors: multiple trauma; cytokines; Disseminated Intravascular Coagulation. The systemic inflammatory response can be associated with DIC where cytokines and chemokines act as key mediators. There is ample evidence that there is considerable cross-talk between inflammatory activation and hemostatic activity. This interaction is bidirectional, so inflammation not only leads to activation of clotting, but activates clotting proteases that also importantly regulate inflammation. Changes in the concentrations of the cytokines G-SCF, Gro-α, IL-6, IL-8, IL-10 and MCP-1 correlated with the severity of the condition of polytraumatized patients, suggesting that these cytokines may be playing protective roles in the immunopathogenesis of polytraumatized patients and thus all these cytokines may be potential reliable biomarkers for predicting the development of CVID syndrome in patients with polytrauma.
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