ANÁLISIS DE LA CORRELACIÓN DE CITOQUINAS INFLAMATORIAS Y DIC EN PACIENTES POLITRAUMADOS
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https://doi.org/10.53612/recisatec.v2i6.148Palabras clave:
Trauma múltiple, citocinas, Coagulación intravascular diseminadaResumen
La coagulación intravascular diseminada (CID) se caracteriza por la activación in vivo del sistema de coagulación, lo que resulta en el depósito intravascular de fibrina y sangrado excesivo. El paciente politraumatizado sufre de inflamación sistémica mediada por citoquinas inflamatorias. En este contexto, el objetivo del presente estudio es relacionar las citoquinas inflamatorias con la condición de coagulación intravascular diseminada en pacientes politraumatizados. La revisión bibliográfica se realizó a partir del relevamiento de artículos científicos encontrados en las principales plataformas de búsqueda de artículos científicos: ScienceDirect, PubMed, SciELO y BIREME, de marzo de 2021 a marzo de 2022, utilizando los descriptores: politraumatismo; citocinas; Coagulación intravascular diseminada. La respuesta inflamatoria sistémica puede estar asociada con DIC donde las citocinas y las quimiocinas actúan como mediadores clave. Existe amplia evidencia de que existe una interferencia considerable entre la activación inflamatoria y la actividad hemostática. Esta interacción es bidireccional, por lo que la inflamación no solo conduce a la activación de la coagulación, sino que también activa las proteasas de la coagulación que también regulan la inflamación de manera importante. Los cambios en las concentraciones de las citoquinas G-SCF, Gro-α, IL-6, IL-8, IL-10 y MCP-1 se correlacionaron con la gravedad de la condición de los pacientes politraumatizados, lo que sugiere que estas citoquinas pueden desempeñar funciones protectoras en la inmunopatogénesis de pacientes politraumatizados y, por lo tanto, todas estas citoquinas pueden ser biomarcadores confiables potenciales para predecir el desarrollo del síndrome CVID en pacientes con politraumatismos.
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