ENVELHECIMENTO IMUNOLÓGICO E IMPLICAÇÕES CLÍNICAS GRAVES EM IDOSOS NA COVID-19

Autores

DOI:

https://doi.org/10.53612/recisatec.v1i5.53

Palavras-chave:

COVID-19, Imunossenescência, Inflammaging

Resumo

A COVID-19, causada pela infecção por SARS-CoV-2, varia de leve a moderado na maioria dos indivíduos previamente saudáveis, mas pode causar doenças com risco de morte ou sintomas debilitantes persistentes em alguns casos. A gravidade da COVID-19 está relacionada à idade, com indivíduos com mais de 65 anos apresentando maior risco de necessitar de cuidados intensivos. Esta é uma pesquisa descritiva, exploratória, do tipo revisão integrativa da literatura com o objetivo explanar o conhecimento atual sobre a interferência do processo de imunosenescência em quadros de maior gravidade por covid-19 em idosos. O envelhecimento se trata de uma involução sistêmica, incluindo o sistema imunológico, acometendo o indivíduo com diversas comorbidades, estando entre elas comorbidades cardíacas, pulmonares e neurológicas que agravam o quadro de vulnerabilidade. O envelhecimento é desencadeado por vários mecanismos, entre os mais relevantes há diminuição dos telômeros, e estresse oxidativo que por sua vez acarretam a outros cenários como senescência de células T, disfunção mitocondrial e inflamação crônica de baixo grau, o que é somado com mecanismo de atuação do próprio vírus causador da COVID-19, como seu fator chave-fechadura envolvendo receptores ECA-2 que possuem mudança de expressão durante o envelhecimento, retratando as interferências deste cenário senescente ao entrar em contato com a covid-19 que contribuem para maior gravidade em idosos.

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Biografia do Autor

Eduardo Lopes Barbosa, Faculdade Estácio de Macapá

Acadêmico do curso de Biomedicina da Faculdade Estácio de Macapá.

Estéphany Miranda Dias, Faculdade Estácio de Macapá

Acadêmica do curso de Biomedicina da Faculdade Estácio de Macapá

Letícia Lorem Vilhena de Castro, Faculdade Estácio de Macapá

Acadêmica do curso de Biomedicina da Faculdade Estácio de Macapá.

Maysa de Vasconcelos Brito, Faculdade Estácio de Macapá

Doutorado em Doenças Tropicais (UFPA); Mestrado em Neurociências e Biologia Celular (UFPA); Graduação em Biomedicina (UFPA); Docente e pesquisadora da Faculdade Estácio de Macapá. 

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Publicado

27/12/2021

Como Citar

Barbosa, E. L., Dias, E. M., Castro, L. L. V. de, & de Vasconcelos Brito, M. (2021). ENVELHECIMENTO IMUNOLÓGICO E IMPLICAÇÕES CLÍNICAS GRAVES EM IDOSOS NA COVID-19. RECISATEC - REVISTA CIENTÍFICA SAÚDE E TECNOLOGIA - ISSN 2763-8405, 1(5), e1553. https://doi.org/10.53612/recisatec.v1i5.53

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