EXPERIMENTAL MODEL OF EX VIVO CARDIAC PERFUSION

Authors

  • Valdir Assis dos Reis Filho

DOI:

https://doi.org/10.53612/recisatec.v2i4.125

Keywords:

cardiac transplant, graft preservation, ex vivo perfusion, isolated heart

Abstract

Isolated organs perfusion systems have been developed and implanted in the transplantation practice, the principal objective is maintaining the stability of the grafts for prolonged times. Ex vivo perfusion provide to preserve cardiac tissue, maintain electrical impulses and establish an adequate metabolic state. New preservation techniques need to be discussed and presented, in order to expand future perspectives to improve myocardial protection in the context of heart transplantation.

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Author Biography

Valdir Assis dos Reis Filho

Instituto Dante Pazzanese de Cardiologia. Faculdade de Ciências Médicas da Santa Casa de São Paulo

References

BACAL, F. et al. 3ª Diretriz Brasileira de Transplante Cardíaco. Arq. Bras. Cardiol., São Paulo, v. 111, n. 2, p. 230-289, Ago. 2018.

BELL, R. M.; MOCANU, M. M.; YELLON, D. M. Retrograde heart perfusion: the Langendorff technique of isolated heart perfusion. J. Mol. Cell. Cardiol., v. 50, n. 6, p. 940-50, 2011. DOI: https://doi.org/10.1016/j.yjmcc.2011.02.018

BOCCHI, E. A. et al. Atualização da diretriz brasileira de insuficiência cardíaca crônica - 2012. Arq. Bras. Cardiol., São Paulo, v. 98, n. 1, supl. 1, p. 1-33, 2012. DOI: https://doi.org/10.1590/S0066-782X2012001000001

CAMP, P. C. Heart transplantation: donor operation for heart and lung transplantation. Oper. Tech. Thorac. Cardiovasc. Surg., v. 15, n. 2, p. 125-37, 2010. DOI: https://doi.org/10.1053/j.optechstcvs.2010.04.003

CHAVES, L.N. F.; CARLOS, D. M. O. Estado nutricional e qualidade de vida de pacientes candidatos a transplante cardíaco. Rev. Bras. Promoç. Saúde., Fortaleza, v. 31, n. 1, p. 1-13, 2018. DOI: https://doi.org/10.5020/18061230.2018.6483

CIUBOTARU, A.; HAVERICH, A. Ex vivo Approach to Treat Failing Organs: Expanding the Limits. Eur. Surg. Res., v. 54, p. 64-74, 2015. DOI: https://doi.org/10.1159/000367942

COLLINS, M. J.; MOAINIE, S. L.; GRIFFITH, B. P.; POSTON, R. S. Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool. Eur. J. Cardiothorac. Surg., v. 34, n. 2, p. 318-325, 2008. DOI: https://doi.org/10.1016/j.ejcts.2008.03.043

DINKHUYSEN, J. J. et al. "Non Working Beating Heart": novo método de proteção miocárdica no transplante cardíaco. Rev. Bras. Cir. Cardiovasc., São José do Rio Preto, v. 26, n. 4, p. 630-634, Dez. 2011. DOI: https://doi.org/10.5935/1678-9741.20110055

LANGENDORFF, O. Untersuchungen am uberlebenden Saugethierherze. Pflügers Arch., v. 61, n. 6, p. 291–332, 1895. DOI: https://doi.org/10.1007/BF01812150

MALBOUISSON, L. M. S.; SANTOS, L. M.; AULER Jr, J. O. C.; CARMONA, M. J.C. Proteção miocárdica em cirurgia cardíaca. Rev. Bras. Anestesiol., Rio de Janeiro, v. 55, n.5, p. 575-585, 2005. DOI: https://doi.org/10.1590/S0034-70942005000500012

MATTE, G. S.; DEL NIDO, P. J. History and use of del Nido cardioplegia solution at Boston Children’s hospital. J. Extra. Corpor. Technol., v. 44, n. 3, p. 98-103, 2012.

MESSER, S.; ARDEHALI, A.; TSUI, S. Normothermic donor heart perfusion: current clinical experience and the future. Transpl. Int., v. 28, n. 6, p. 634-642, 2014. DOI: https://doi.org/10.1111/tri.12361

O’BLENES, S. B.; FRIESEN, C. H.; ALI, A.; HOWLETT, S. Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia. J. Thorac. Cardiovasc. Surg., v. 141, n. 3, p. 762–769, 2011. DOI: https://doi.org/10.1016/j.jtcvs.2010.06.004

OLIVEIRA, M. A. B.; BRANDI, A. C.; SANTOS, C. A. et al . Modalidades de parada cardíaca induzida: hipercalemia e hipocalcemia - revisão de literatura. Rev. Bras. Cir. Cardiovasc., São José do Rio Preto, v. 29, n. 3, p. 432-436, Set. 2014.

PELGRIM, G. J.; DAS, M.; HABERLAND, U. et al. Development of an ex vivo, beating heart model for CT myocardial perfusion. BioMed. Res. Int., p. 1-8, 2015. DOI: https://doi.org/10.1155/2015/412716

SOUZA, M. H. L.; ELIAS, D. O. Fundamentos da Circulação Extracorpórea. 2. ed. Rio de Janeiro: Alfa Rio; 2006.

SOUILAMAS, R.; SOUILAMAS, J. I.; SAUERESSIG, M.; BRIOT, R. Advanced normothermic ex vivo lung maintenance using the mobile Organ Care System. J. Heart. Lung. Transplant., v. 30, n. 7, p. 847-848, 2011. DOI: https://doi.org/10.1016/j.healun.2011.02.005

TSUKASHITA, M.; NAKA, Y. Organ care system for heart procurement and strategies to reduce primary graf failure afer heart transplant. Oper. Tech. Thorac. Cardiovasc. Surg., v. 20, n. 3, p. 322-334, 2015. DOI: https://doi.org/10.1053/j.optechstcvs.2015.12.002

VAN RAEMDONCK, D.; NEYRINCK, A. et al. Machine perfusion in organ transplantation: a tool for ex-vivo graft conditioning with mesenchymal stem cells? Curr. Opin. Organ. Transplant., v. 18, n. 1, p. 24-33, 2013. DOI: https://doi.org/10.1097/MOT.0b013e32835c494f

WHITE, C. W.; AMBROSE, E.; MULLER, A.; LI, Y.; LE, H.; HIEBERT, B. et al. Assessment of donor heart viability during ex vivo heart perfusion. Can. J. Physiol. Pharmacol., v. 93, n. 10, p. 893–901, 2015. DOI: https://doi.org/10.1139/cjpp-2014-0474

Published

2022-04-20

How to Cite

Assis dos Reis Filho, V. (2022). EXPERIMENTAL MODEL OF EX VIVO CARDIAC PERFUSION. RECISATEC - SCIENTIFIC JOURNAL HEALTH AND TECHNOLOGY, 2(4), e24125. https://doi.org/10.53612/recisatec.v2i4.125

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REVIEWS - TRANSLATIONS - INTERVIEWS - BOOK CHAPTER - SCIENTIFIC REPORTS

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